Immunotherapy: Open Access
Open Access

Margareta Holgersson

Publications

• Research Article
  Evaluation of Changes in Skin Reactivity by Skin Prick Test Titration
  Author(s): Sten Dreborg, Margareta Holgersson and Christian MollerSten Dreborg, Margareta Holgersson and Christian Moller
  
  Background: Parallel line bioassay (PLBA) has been acknowledged being the gold standard for estimation of changes in skin reactivity during (immuno-)therapy. Objective: To study changes in skin prick test (SPT) estimated by skin prick test titration, wheal area and sum of wheal areas in relation to PLBA. Methods: Data from a published immunotherapy trial using skin titration with half 10 log steps were evaluated using endpoint titration, wheal areas, histamine equivalent allergen concentration using PLBA as gold standard. Results: Endpoint titration and PLBA correlated (r=0.76) and the slope of the correlation, b (0.8) was not significantly different from 1, i.e. expressed the same result, were interchangeable. Furthermore, the result was expressed in change in allergen concentration, Ca. The a.. View More»
  DOI: 10.4172/2471-9552.1000116

  Abstract PDF

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