Journal of Research and Development
Open Access

Margari Z

Publications

• Review Article
  Efficacy of Low Dose Tenecteplase in Restoring Vessel Patency in a Clinically Relevant Large Animal Experimental Model
  Author(s): Tseliou E, Ntalianis A, Diakos N, Pozios H, Repasos V, Katsaros F, Dimopoulos S, Kontopidi V, Margari Z and Nanas JNTseliou E, Ntalianis A, Diakos N, Pozios H, Repasos V, Katsaros F, Dimopoulos S, Kontopidi V, Margari Z and Nanas JN
  
  Background: We tested whether tenecteplase, a recombinant fibrin-specific plasminogen activator can induce efficient thrombolysis in lower doses than the hitherto indicated, compared to full-dose therapy for vessel thrombosis. Methods: Farm pigs (30-35 kg, n=23) were imposed in a clinically relevant model of common carotid-arteries (CA) and the left-anterior-descending (LAD) artery below the first diagonal occlusion. The vessels were initially externally injured followed by an appropriate for the vessel dose of thrombin. Occlusion was achieved in 80% for the LAD and 57% for the CA. Post occlusion the animals were allocated to one of the following groups: Group A) halfdose tenecteplase (2000IU); Group B) Full dose tenecteplase (5000IU); Group C) saline only. All animals received heparin and antiplatelet agents. The animals were followed-up for .. View More»
  

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