Journal of Cell Science & Therapy
Open Access

Maria Felice Brizzi

Publications

• Short Communication
  Protective Role of Stem Cell Derived Extracellular Vesicles in an In Vitro Model of Hyperglycemia-Induced Endothelial Injury
  Author(s): Chiara Gai, Yonathan Gomez, Ciro Tetta, Maria Felice Brizzi and Giovanni Camussi Chiara Gai, Yonathan Gomez, Ciro Tetta, Maria Felice Brizzi and Giovanni Camussi
  
  Background: Adipose and bone marrow derived mesenchymal stem cells are two populations of multipotent adult stem cells with immunosuppressive, anti-inflammatory, and regenerative properties. It has been previously described that extracellular vesicles (EVs) derived from stem cells possess pro-regenerative and pro-angiogenic abilities. Hyperglycemia is a pathological condition affecting diabetic patients. Long term effects of hyperglycemia are endothelial dysfunction and vascular lesions leading to diabetic microangiopathy. The aim of the present study was to evaluate whether stem cell-derived EVs may inhibit endothelial cells dysfunction induced by hyperglycemia to mimic human microangiopathy. Methods: We set up an in vitro hyperglycemic model by culturing human microvascular endothelial cells in hyperglycemic constant or intermittent condit.. View More»
  DOI: 10.4172/2157-7013.1000264

  Abstract PDF

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