Clinical & Experimental Cardiology
Open Access

Maria Josep Pulgarin

Publications

• Research Article
  Molecular Changes of the Angiotensin Converting Enzyme 2 Pathway in Myocardial Tissue from Heart Failure Patients Undergoing Heart Transplantation
  Author(s): Montserrat Batlle, Eulàlia Roig, Maria Josep Pulgarin, Begoña Campos, José Ramírez, Jose Luis Pomar, Marta Farrero, Maria Ángeles Castel, Montserrat Cardona, Mercé Roqué, Josefina Orús, Ramon Cartaña and Fèlix Perez-VillaMontserrat Batlle, Eulàlia Roig, Maria Josep Pulgarin, Begoña Campos, José Ramírez, Jose Luis Pomar, Marta Farrero, Maria Ángeles Castel, Montserrat Cardona, Mercé Roqué, Josefina Orús, Ramon Cartaña and Fèlix Perez-Villa
  
  Background: The angiotensin-converting enzyme homologue ACE2 and the peptide angiotensin 1-7 (Ang 1-7) have antifibrotic effects, but it is not understood whether they have a protective role in cardiac remodeling. We aimed to analyze the Ang 1-7 Mas receptor and ACE2 expresion levels and their relationship with fibrotic and remodeling factors in human heart failure (HF) and compared them with non-pathological human hearts.Methods: This was a human case-control study in which two groups of samples were analyzed. Controls were organ donors without cardiovascular pathology, but whose heart could not be used for transplantation. Cases were patients with end-stage HF and left ventricle samples were harvested right after the heart transplantation surgery. They were either kept with liquid nitrogen until their analysis or w.. View More»
  DOI: 10.4172/2155-9880.S9-004

  Abstract PDF

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