Journal of Proteomics & Bioinformatics
Open Access

Marie W. Wooten

Publications

• Research Article
  Defining an Embedded Code for Protein Ubiquitination
  Author(s): Trafina Jadhav and Marie W. Wooten Trafina Jadhav and Marie W. Wooten
  
  It has been more than 30 years since the initial report of the discovery of ubiquitin as an 8.5 kDa protein of unknown function expressed universally in living cells. And still, protein modification by covalent conjugation of the ubiquitin molecule is one of the most dynamic posttranslational modifications studied in terms of biochemistry and cell physiology. Ubiquitination plays a central regulatory role in number of eukaryotic cellular processes such as receptor endocytosis, growth-factor signaling, cell-cycle control, transcription, DNA repair, gene silencing, and stress response. Ubiquitin conjugation is a three step concerted action of the E1-E2-E3 enzymes that produces a modified protein. In this review we investigate studies undertaken to identify both ubiquitin and SUMO (small ubiquitin-related modifier) substrates with the goal of understanding how lysine sel.. View More»
  DOI: 10.4172/jpb.1000091

  Abstract PDF

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