Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Marie-Noelle Kallas-Chemaly
Lebanon
Research Article
Establishment of Reference Values of Serum PTH in a Middle-Eastern Healthy Population Using 2nd and 3rd Generation PTH Assays
Author(s): Marie-Helene Gannage-Yared, Marie-Noelle Kallas-Chemaly and Ghassan SleilatyMarie-Helene Gannage-Yared, Marie-Noelle Kallas-Chemaly and Ghassan Sleilaty
Background: The purpose of the current study is to determine PTH reference values in vitamin D replete Lebanese adults using a 2nd and 3rd generation of PTH assays, and to look at the factors that affect PTH variations.
Methods: Fasting PTH was measured using 2nd and 3rd generation Diasorin PTH assays in 339 vitamin D replete healthy subjects aged 18 to 63 years (230 men and 109 women) who have normal calcium levels and an eGFR ≥ 60 ml/mn. 25(OH) vitamin D (25(OH)D) was measured using the Diasorin assay.
Results: For the 2nd PTH generation, median (IQR) levels were 48.9 [34.9-66.0] pg/ml and its 2.5th-97.5th percentile values were 19.7-110.5 pg/ml for 25(OH)D values between 20 ng/ml and 30 ng/ml, and 19.7-110.7 pg/ml for 25(OH)D values ≥ 30 ng/ml. For the 3rd PTH generation the median (IQR) values were 23.9.. View More»