Journal of Infectious Diseases & Preventive Medicine
Open Access

Marike Cockeran

Publications

• Research Article
  The Potential Effect of Using the Cockcroft-Gault Method on Tenofovir-Associated Renal Impairment Reports and on Clinical Decisions Regarding Tenofovir Use in Individual Patients: Implications for the Future
  Author(s): Francis Kalemeera, Marike Cockeran, Mwangana Mubita, Dan Kibuule, Ester Naikaku, Amos Massele and Brian Godman Francis Kalemeera, Marike Cockeran, Mwangana Mubita, Dan Kibuule, Ester Naikaku, Amos Massele and Brian Godman
  
  Introduction: In Namibia, the Cockcroft-Gault (C-G) method is recommended for monitoring renal function in HIV patients receiving Tenofovir Disoproxil Fumarate (TDF)-containing Combination Antiretroviral Therapy (cART). However, there are concerns with the potential over-reporting of TDF-associated renal impairment. Methods: Retrospective study comparing the renal function of patients receiving 2nd line cART with either C-G or Chronic Kidney Disease-Epidemiology (CKD-EPI) methods. Results: 71 patients were included. The majority (62%) received TDF-containing 1st line ART. All received 2ndline cART containing TDF/Lamivudine (3TC)/Zidovudine (AZT) and LPV/r. Before switching to 2nd-line cART, 40.8% and 8.5% had abnormal eGFR according to C-G and CKD-EPI methods respectively. During 2nd-line cART, 47.9% and 7% of pati.. View More»
  DOI: 10.4172/2329-8731.1000170

  Abstract PDF

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