Journal of Clinical and Cellular Immunology
Open Access

Mario Mastrolonardo

Publications

• Research Article
  Alterations of Mitochondrial Respiration and Complex I Activity in Mononucleate Cells from Psoriatic Patients: Possible Involvement of GRIM-19-STAT3α/β
  Author(s): Rosella Scrima, Claudia Piccoli, Giovanni Quarato, Maria Ripoli, Mario Mastrolonardo and Nazzareno CapitanioRosella Scrima, Claudia Piccoli, Giovanni Quarato, Maria Ripoli, Mario Mastrolonardo and Nazzareno Capitanio
  
  Objective: Although the pathogenesis of psoriasis is largely unknown accumulating evidences configure it as an immune-mediated disease determined through cytokines-mediated positive loops between activated lymphocytes subsets and keratinocytes. Mitochondria in addition to their role in the cell bioenergetics are now recognized as a decisional hub in controlling the immunological response. In the present study we compared mitochondria-related functions of PBMC between psoriatic patients and healthy controls. Methods: Freshly isolated PBMC from eleven psoriatic patients and nine healthy controls were subjected to mitochondria-dependent respiratory activity measurements by high-resolution oxymetry and the specific activity of respiratory chain complexes assessed by spectrophotometric assays. Quantitative RT-PCR and immunoblotting were applied to .. View More»
  DOI: 10.4172/2155-9899.1000184

  Abstract PDF

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