Clinical & Experimental Cardiology
Open Access

Mario Udovicic

Publications

• Research Article
  Mortal Furosemide-Hypokalemia-Disturbances in Rats NO-System Related Shorten Survival by L-NAME. Therapy Benefit with BPC 157 Peptide More Than With L-Arginine
  Author(s): Diana Balenovic, Ivan Barisic, Ingrid Prkacin, Ivan Horvat, Mario Udovicic, Sandra Uzun, Dean Strinic, Damira Pevec, Domagoj Drmic, Bozo Radic, Darija Bardak, Mirna Zlatar, Gorana Aralica, Martina Lovric Bencic, Jadranka Separovic Hanzevacki, Zeljko Romic, Aleksandra Sindic, Sven Seiwerth and Predrag Sikiric Diana Balenovic, Ivan Barisic, Ingrid Prkacin, Ivan Horvat, Mario Udovicic, Sandra Uzun, Dean Strinic, Damira Pevec, Domagoj Drmic, Bozo Radic, Darija Bardak, Mirna Zlatar, Gorana Aralica, Martina Lovric Bencic, Jadranka Separovic Hanzevacki, Zeljko Romic, Aleksandra Sindic, Sven Seiwerth and Predrag Sikiric
  
  Background: We focused on NO-system-relations (worsening/amelioration) of furosemide (100 mg/kg intraperitoneally)-diuresis-hypokalemia mortal course in rats and beneficial effect of BPC 157 therapy. Methods: Electrocardiographically 90-150 min post-furosemide application duration of PR, RR, QRS, QT intervals, P, R, S, T waves and its amplitude as well were analysed along with appearance of AV block, ventricular premature beats, ventricular tachycardia. Clinically, skeletal muscle myoclonal activity and lethality at 150 min were also analysed. Results: All NO-system-related agents (alone and/or combined, before/after furosemide) not changed hypokalemia and all averted to some extent furosemide-forced diuresis. NOS-blocker, L-NAME (5 mg/kg intraperitoneally) accelerated mortality, aggravated cardiac and extra-cardiac manifestations, thereby, NO-systemrelated. Prevented hypokalemia-mort.. View More»
  DOI: 10.4172/2155-9880.1000201

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