Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Mark Aragones
Philippines
Review Article
The Role of B Cells in Autoimmunity: Insights on B Lymphocyte Stimulation (Blys) as a Target for Biologics in Systemic Lupus Erythematosus
Author(s): Evan S Vista and Mark AragonesEvan S Vista and Mark Aragones
Systemic lupus erythematosus (SLE) is a heterogenous condition with significant impact on morbidity and mortality among affected individuals, usually young females during their most productive stage in life. The production of pathogenic autoantibodies has been the classical hallmark for the disease. B cells, the precursor of the antibody producing plasma cells, are believed to play a central role in SLE disease activity. It has long been considered a difficult disease to manage and diagnose due to its wide raging manifestations and severity. This systemic autoimmune condition has attracted many clinicians and researchers for decades in the hope of fully unraveling the disease pathogenesis in order to come up with more effective treatments. Treatment strategies have been broadly directed at dampening the immune response with consequential adverse effects in the long term care of diseas.. View More»
DOI:
10.4172/2155-9899.1000360