Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Marlyn Mohd
Malaysia
Research Article
Urinary Monocyte Chemoattractant Protein and Lupus Nephritis Activity
Author(s): Sabah Alharazy, Norella CT Kong, Marlyn Mohd, Shamsul A Shah, Arbaiyah Báin and Abdul Halim Abdul GaforSabah Alharazy, Norella CT Kong, Marlyn Mohd, Shamsul A Shah, Arbaiyah Báin and Abdul Halim Abdul Gafor
Objective: Monocyte chemoattractant protein-1 (MCP-1) is reported to be associated with lupus nephritis (LN) activity. We therefore investigated urinary MCP-1 (uMCP-1) in patients with biopsy proven LN.Methods: This was a cross-sectional observational study in which uMCP-1 levels and the standard parameters of LN activity were measured in these patients.Results: One hundred patients were recruited: 47 with active and 53 inactive LN. uMCP-1 levels were increased in those with active LN [9,317.5 pg/mg creatinine (5,48.3-40,170)] compared to those with inactive LN [3,682 pg/ mg creatinine (0-23,866)] (p<0.001). uMCP-1 correlated with proteinuria (r=0.39, p=0.001), serum albumin (r=-0.35, p=0.001) and SLEDAI-2K (renal) (r=0.39, p=0.001). Area under receiver operating characteristic (AUROC) curve for uMCP-1 was 0.82 (p=0.001.. View More»
DOI:
10.4172/2155-9899.1000187