Pancreatic Disorders & Therapy
Open Access

Martin D McCarter

Publications

• Research Article
  Thrombelastography Delineates Hypercoagulability in an Immunocompetent Murine Model of Metastatic Pancreatic Cancer
  Author(s): Karen K Lo, Ernest E Moore, Philip M Mehler, Theresa Chin, Fredric Pieracci, Martin D McCarter, Christopher C Silliman and Carlton C Barnett Jr Karen K Lo, Ernest E Moore, Philip M Mehler, Theresa Chin, Fredric Pieracci, Martin D McCarter, Christopher C Silliman and Carlton C Barnett Jr
  
  Introduction: Pancreatic cancer has the highest risk for venous thrombosis of all gastrointestinal malignancies. Although there are recent consensus guidelines for anticoagulation in cancer patients, the implimentation of prophlaxis anticoagulation is still sub optimal. Current diagnostic tests are unreliable in predicting cancer related hypercoagulability, leading to interest in examining the kinetics of clot formation by thrombelastography. We hypothesize that thrombelastography will characterize hypercoagulability in a metastatic murine model of pancreatic adenocarcinoma. Methods: C57/BL6 mice, age 7-9 weeks, underwent splenic inoculation with 2.5×105 Pan02 murine pancreatic adenocarcinoma cells. At necropsy, (7 weeks) blood was collected with citrate (1:10 ratio) and TEG was obtained on Thrombelastograph® Analyzer. TEG was compare.. View More»
  DOI: 10.4172/2165-7092.1000126

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