Rheumatology: Current Research
Open Access

Maryam Pashaiasl

Publications

• Research Article
  An Analysis on Pyrin E148Q Mutations in Patients with Refractory Rheumatoid Arthritis
  Author(s): Abbas Mirzaei, Sousan Kolahi, Arash Ahmadi, Mohammadreza Nakhjavani and Maryam Pashaiasl Abbas Mirzaei, Sousan Kolahi, Arash Ahmadi, Mohammadreza Nakhjavani and Maryam Pashaiasl
  
  Objective: Rheumatoid arthritis (RA) is an autoimmune disease with lifelong disability in adults. Given the high prevalence of Mediterranean fever and its overlapping and modulatory effects on autoimmune diseases, we analyzed molecular mutation in exon 2 of MEFV gene in patients with refractory RA and healthy subjects as a control group. Methods: Thirty four patients with refractory RA and fifty healthy controls were conducted in this study and their DNA samples were analyzed. We studied the most common exon 2 variation on MEFV gene which known as E148Q. At the end of this study, we compared the results of both groups. Results: The mean age of patients with refractory RA were 43.8 ± 7.7 years and disease duration was 49.8 ± 7.36 months. The mean of DAS 28 (Disease Activity score) of patien.. View More»
  DOI: 10.4172/2161-1149.1000232

  Abstract PDF

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