Journal of Glycobiology
Open Access

Massoud Dadras

Publications

• Research Article
  Influence of the Macro- and/or Microstructure of Cross-Linked Hyaluronic Acid Hydrogels on the Release of Two Model Drugs
  Author(s): Karine Mondon, Massoud Dadras, Jeremy Tillier and Samuel Gavard MolliardKarine Mondon, Massoud Dadras, Jeremy Tillier and Samuel Gavard Molliard
  
  Injectable hyaluronic acid (HA) hydrogels, crosslinked with 1,4-butanediol diglycidyl ether (BDDE), are widely used in aesthetic medicine. Due to their high clinical tolerance, HA hydrogels are thought to be applicable as injectable drug delivery systems. Here, HA matrix structures of BDDE-crosslinked HA hydrogels were analysed, and the effects of the structures on the release of two model drugs were assessed. Seven crosslinked HA hydrogels were observed by optical microscopy and cryo scanning electron microscopy (cryo-SEM). We observed three specific matrix macrostructures under optical microscopy: two had a “spider web”-like structure, three had a particulate structure, and two had an intermediate structure. These differences were less evident under cryo-SEM, where all hydrogels exhibited fibrous microstructures of different homogeneity levels, with pore sizes between 0... View More»
  DOI: 10.4172/2168-958X.1000119

  Abstract PDF

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