Journal of Proteomics & Bioinformatics
Open Access

Max Costa

Publications

• Research Article
  Plasma Anti-Glycan Antibody Profiles Associated with Nickel level in Urine
  Author(s): Marko Vuskovic, Anna-Maria Barbuti, Emma Goldsmith-Rooney, Laura Glassman, Nicolai Bovin, Harvey Pass, Kam-Meng Tchou-Wong, Meichi Chen, Bing Yan, Jingping Niu, Qingshan Qu, Max Costa and Margaret HuflejtMarko Vuskovic, Anna-Maria Barbuti, Emma Goldsmith-Rooney, Laura Glassman, Nicolai Bovin, Harvey Pass, Kam-Meng Tchou-Wong, Meichi Chen, Bing Yan, Jingping Niu, Qingshan Qu, Max Costa and Margaret Huflejt
  
  Nickel (Ni) compounds are widely used in industrial and commercial products including household and cooking utensils, jewelry, dental appliances and implants. Occupational exposure to nickel is associated with an increased risk for lung and nasal cancers, is the most common cause of contact dermatitis and has an extensive effect on the immune system. The purpose of this study was two-fold: (i) to evaluate immune response to the occupational exposure to nickel measured by the presence of anti-glycan antibodies (AGA) using a new biomarker-discovery platform based on printed glycan arrays (PGA), and (ii) to evaluate and compile a sequence of bioinformatics and statistical methods which are specifically relevant to PGA-derived information and to identification of putative “Ni toxicity signature”. The PGAs are similar to DNA microarrays, but contain deposits of various carbohyd.. View More»
  DOI: 10.4172/jpb.1000295

  Abstract PDF

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