Rheumatology: Current Research
Open Access

Melanie Cisewski

Publications

• Research Article
  Characterisation of the Inflammatory Infiltrate in Deep Lesions of Localized Scleroderma Compared to Erythema Nodosum
  Author(s): Thilo Gambichler, Sarah Terras, Melanie Cisewski, Markus Stücker, Falk G. Bechara and Alexander Kreuter Thilo Gambichler, Sarah Terras, Melanie Cisewski, Markus Stücker, Falk G. Bechara and Alexander Kreuter
  
  Background: Involvement of deep structures, predominantly the subcutis, may occur in many subtypes of localized scleroderma (LS). Objectives: The purpose of the present study was to characterize the inflammatory infiltrate in deep lesions of LS (DLLS) with affection of the subcutaneous fat tissue, and to compare the findings with erythema nodosum (EN). Methods: We assessed 22 patients with DLLS lesions who predominantly suffered from limited (n=8), generalized (n=8), linear (n=4), or deep (n=2) LS. Moreover, we studied 20 patients with EN. In each patient, a spindle-shaped full thickness skin excision was performed before the initiation of any antiphlogistic or immunosuppressive treatment. Biopsy specimens were processed for routine histology and immunohistochemistry for CD3, CD4, CD8, CD20, CD15, and CD68. .. View More»
  DOI: 10.4172/2161-1149.1000141

  Abstract PDF

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