Journal of Clinical and Experimental Ophthalmology
Open Access

Melissa M Brown

Publications

• Research Article
  Combination Therapy with Dietary Zeaxanthin for Neovascular Age Related Macular Degeneration. A Randomized Clinical Trial
  Author(s): R Joseph Olk, Enrique Peralta, Dennis L Gierhart, Melissa M Brown, Gary C Brown R Joseph Olk, Enrique Peralta, Dennis L Gierhart, Melissa M Brown, Gary C Brown
  
  Purpose: A previous comparative interventional study suggested oral zeaxanthin added to triple therapy of intravitreal bevacizumab, intravitreal corticosteroids and photodynamic therapy with verteporfin for the treatment of neovascular age-related macular degeneration (NVAMD) was comparatively effective and cost-effective. A randomized clinical trial was undertaken to confirm these effects. Methodology: A two-year, triple-blinded, randomized clinical trial enrolled 144 participants (168 eyes) with NVAMD to triple therapy (TT) (intravitreal bevacizumab, reduced-fluence photodynamic therapy and intravitreal dexamethasone) or the same triple therapy with oral zeaxanthin (TTZ) supplementation, 20 mg daily. Data were modeled out to the 11-year life expectancy of the average participant. Results: At 24-months, twenty-sev.. View More»
  DOI: 10.4172/2155-9570.1000692

  Abstract PDF

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