Clinical & Experimental Cardiology
Open Access

Metsada Pasmanik-Chor

Publications

• Research Article
  Renal Failure is Associated with Driving of Gene Expression towards Cardiac Hypertrophy and Reduced Mitochondrial Activity
  Author(s): Michal EM, Metsada PC, Jeremy BS, Sofia MA, Pavel G, Ido L, Shelly K, Varda OK, Jonathan S, Einat H, and Gad K Michal EM, Metsada PC, Jeremy BS, Sofia MA, Pavel G, Ido L, Shelly K, Varda OK, Jonathan S, Einat H, and Gad K
  
  Background: The clinical concomitant presentation of cardiac and renal failure (RF) has been referred to as the “cardiorenal syndrome” (CRS), whereby acute or chronic dysfunction of one organ induces acute or chronic dysfunction of the other. To improve our understanding of the cellular and molecular mechanisms underlying the development and diversification of CRS we established a model for CRS and studied the unique gene expression patterns associated with this syndrome. Methods and Results: We have utilized a rat model in which an acute myocardial infarction (AMI) was induced on the background of subtotal nephrectomy. Changes in cardiac functions and gene expression were analyzed as detailed below. The data demonstrate that chronic RF (CRF) enhances fibrosis of the cardiac tissue. The gene chip array data detect overexpression .. View More»
  DOI: 10.4172/2155-9880.1000184

  Abstract PDF

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