International Journal of Physical Medicine & Rehabilitation
Open Access

Michael D. Noseworthy

Publications

• Research Article
  Advanced Skeletal Muscle MR Imaging Approaches in the Assessment of Muscular Dystrophies
  Author(s): Dinesh A. Kumbhare, Alyaa H. Elzibak, Alireza Akbari and Michael D. Noseworthy Dinesh A. Kumbhare, Alyaa H. Elzibak, Alireza Akbari and Michael D. Noseworthy
  
  Muscular dystrophies (MDs) are inherited diseases that lead to progressive skeletal muscle weakness and functional decline. Currently, the diagnosis is generally made on clinical grounds and confirmed by genetic testing, serologic assessments, neurophysiologic measurements or muscle biopsy. Given our understanding of the pathophysiology of these dystrophies, advancements in magnetic resonance imaging (MRI) techniques may assist clinicians in identification and monitoring of skeletal muscle disease progression in MDs using non-invasive approaches. In this article, we review MR imaging techniques that have been used to quantify skeletal muscle involvement in the various muscle dystrophies, such as in vivo spectroscopic procedures to quantify lipids (1H), muscle bioenergetics (31P) or cellular function (23Na). We also summarize studies that have used T2 relaxation measur.. View More»
  DOI: 10.4172/2329-9096.1000248

  Abstract PDF

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