Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-77-2385-9429
ISSN: 2157-7609
+44-77-2385-9429
Michael N Musila
P. O. Box 43844, 00100, Nairobi
Kenya
Research Article
Acute and Sub-Chronic Oral Toxicity Study of Methanolic Extract of Caesalpinia volkensii (Harms)
Author(s): Michael N Musila, David N Ngai, Jane W Mbiri, Shardrack M Njagi, Wilton M Mbinda and Mathew P NgugiMichael N Musila, David N Ngai, Jane W Mbiri, Shardrack M Njagi, Wilton M Mbinda and Mathew P Ngugi
Medicinal plant Caesalpinia volkensii is used to treat Malaria, conjunctivitis, retinoblastoma, and eyelid swelling as well as gonorrhoea and bilharzia. Animal toxicity information on this plant is limited. This medicinal plant was collected in Embu County in Kenya to evaluate its Acute and sub-chronic toxicity using Wistar rats. The rats were orally administered with different doses of the plants extracts. They were weighed on first day and after every 7 days during treatment with the extract. Signs of toxicity were also observed. After 28 days, the rats were sacrificed and blood samples taken for full hemogram, renal and liver function tests. Weight of internal organs was also recorded. Data was analysed using Minitab statistical software version 17. In acute toxicity studies, C. volkensii extracts did not result to death at extract dose of 2000 mg/kg body weight. In sub-chronic tox.. View More»
DOI:
10.4172/2157-7609.1000222