Journal of Proteomics & Bioinformatics
Open Access

Michael R Freeman

Publications

• Review Article
  Technologies and Challenges in Proteomic Analysis of Protein S-acylation
  Author(s): Bo Zhou, Mingrui An, Michael R Freeman and Wei YangBo Zhou, Mingrui An, Michael R Freeman and Wei Yang
  
  Protein S-acylation (also called palmitoylation) is a pervasive post-translational modification that plays critical roles in regulating protein trafficking, localization, stability, activity, and complex formation. The past decade has witnessed tremendous advances in the study of protein S-acylation, largely owing to the development of novel S-acylproteomics technologies. In this review, we summarize current S-acylproteomics approaches, critically review published S-acylproteomics studies, and envision future directions for the burgeoning S-acylproteomics field. Emerging S-acylproteomics technologies promise to shed new light on this distinct post-translational modification and facilitate the discovery of new disease mechanisms, biomarkers, and therapeutic targets... View More»
  DOI: 10.4172/jpb.1000327

  Abstract PDF

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