Reproductive System & Sexual Disorders: Current Research
Open Access

Michelle A. Williams

Publications

• Research Article
  Differential Expression of HtrA1 and ADAM12 in Placentas from Preeclamptic and Normotensive Pregnancies
  Author(s): Daniel A. Enquobahrie, Karin Hevner, Chunfang Qiu, Dejene F. Abetew, Tanya K. Sorensen and Michelle A. WilliamsDaniel A. Enquobahrie, Karin Hevner, Chunfang Qiu, Dejene F. Abetew, Tanya K. Sorensen and Michelle A. Williams
  
  Background: High temperature requirement factor A 1 (HtrA1) and A Disintegrin And Metalloproteinase 12 (ADAM12), which play roles in placental implantation and placental growth, have been implicated in the pathogenesis of preeclampsia. Methods: We investigated relative mRNA expression of both genes in placental tissues from women with preeclampsia (N = 18) (average gestational age 36 weeks) and an equal number of women with normotensive pregnancies (average gestational age 39 weeks). Real-time polymerase chain reaction was used to measure mRNA extracted from term placental biopsies. Differential gene expression was evaluated using Student’s T-test and fold change analyses. Results: Statistically significant increases in placental HtrA1 (1.69-fold, p = 0.030) and ADAM12 (1.48-fold, p =0.010) mRNA expression were o.. View More»
  DOI: 10.4172/2161-038X.1000110

  Abstract PDF

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