Endocrinology & Metabolic Syndrome
Open Access

Miguel NL

Publications

• Research Article
  Stress during Lactation Affects Fatty Acid Amide Hydrolase Protein Expression in Adipose Tissue and Liver of Adult Mice
  Author(s): Valeska AC, Carina AV, Paula P, Ana MR and Miguel NL Valeska AC, Carina AV, Paula P, Ana MR and Miguel NL
  
  CIntroduction: Early stress alters the endo-cannabinoid system of tissues involved in energy homeostasis, leading to long term consequences associated to hormonal and metabolic disruptions associated to overweight/obesity and insulin resistance. We have previously reported a decreased Anandamide (AEA)-hydrolysing activity in liver and epididymal fat of adult mice previously subjected to stress during lactation, a result that may indicate reduced activity of the enzyme fatty acid amide hydrolase present in both tissues (FAAH; able to hydrolyse the endocannabinoid AEA). Objective: Since at present it is unknown whether early stress affects FAAH gene and/or protein expression in liver and adipose tissue during adulthood, we have performed studies with the aim of evaluating these parameters. Methods: Male mice pups wer.. View More»
  DOI: 10.4172/2161-1017.1000158

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