Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
Miguel NL
Institute of Nutrition and Food Technology (INTA),
El Líbano 5524, Santiago
Chile
Research Article
Stress during Lactation Affects Fatty Acid Amide Hydrolase Protein Expression in Adipose Tissue and Liver of Adult Mice
Author(s): Valeska AC, Carina AV, Paula P, Ana MR and Miguel NLValeska AC, Carina AV, Paula P, Ana MR and Miguel NL
CIntroduction: Early stress alters the endo-cannabinoid system of tissues involved in energy homeostasis, leading to long term consequences associated to hormonal and metabolic disruptions associated to overweight/obesity and insulin resistance. We have previously reported a decreased Anandamide (AEA)-hydrolysing activity in liver and epididymal fat of adult mice previously subjected to stress during lactation, a result that may indicate reduced activity of the enzyme fatty acid amide hydrolase present in both tissues (FAAH; able to hydrolyse the endocannabinoid AEA).
Objective: Since at present it is unknown whether early stress affects FAAH gene and/or protein expression in liver and adipose tissue during adulthood, we have performed studies with the aim of evaluating these parameters.
Methods: Male mice pups wer.. View More»
DOI:
10.4172/2161-1017.1000158