Journal of Nutrition & Food Sciences
Open Access

Mikhael DM

Publications

• Research Article
  Modulation of Oxidative Damage by Green and Black Tea: Role of Smoking and Gender in a Randomized Trial
  Author(s): Hakim IA, Garland L, Harris R, Cordova CA, Mikhael DM and Chow HHS Hakim IA, Garland L, Harris R, Cordova CA, Mikhael DM and Chow HHS
  
  Background: Oxidative stress has been implicated as an important modulator of human health and can play a role in both disease prevention and disease development. Objectives: The overall goal of this study was to determine the effects of high tea consumption on biological markers of oxidative stress that mediate lung cancer risk, including, 8-hydroxydeoxy-guanosine (8-OHdG) and F2-isoprostanes (8-iso-PGF2α). Design: We completed a 6-month randomized, controlled, double-blinded trial in a group of former and current smokers who were randomized to receive green or black tea preparations or a matching placebo. Results: A total of 146 participants (80 females and 66 males) completed the study. At the end of the 6-month intervention, female smokers in the green tea group showed a 35% decrease (p=0.04) in DNA damage while female former smoke.. View More»
  DOI: 10.4172/2155-9600.1000633

  Abstract PDF

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