Clinical & Experimental Cardiology
Open Access

Mikkelsson J

Publications

• Research Article
  Bß-Fibrinogen Gene Promoter –455 G/A Polymorphism Associates with Severity of Coronary Artery Stenosis in Male Victims of Sudden Pre-Hospital Death
  Author(s): Martiskainen, Mikkelsson, Goebeler S, Ilveskoski E and Karhunen PJMartiskainen, Mikkelsson, Goebeler S, Ilveskoski E and Karhunen PJ
  
  Background and Purpose: Elevated fibrinogen levels are associated with the risk of atherosclerotic disease and affected by smoking. In haplotype analyses, the A-allele of the -455 G/A promoter polymorphism of the Bβ-fibrinogen gene (FGB) was most strongly associated with elevated fibrinogen levels. The association of the FGB –455 G/A polymorphism with coronary artery disease (CAD) and its complications have not been studied at the vessel-wall level. Methods: We measured coronary stenosis as well as coronary and aortic atherosclerotic areas in a prospective autopsy series of 300 middle-aged (33-69 years) men (the Helsinki Sudden Death Study). FGB -455 G/A genotype was determined by PCR. Results: Genotype distributions were 69.9%, 24.9%, and 5.2% for GG, GA and AA, respectively. In a logistic regression model .. View More»
  DOI: 10.4172/2155-9880.1000158

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