Translational Medicine
Open Access

Miller RH

Publications

• Review Article
  The Power and Pitfalls of Strategies for Selective Ablation of Oligodendrocytes in the Vertebrate CNS
  Author(s): Caprariello AV and Miller RHCaprariello AV and Miller RH
  
  Normal functioning of the mammalian Central Nervous System (CNS) depends on a high degree of interaction between its constitutive cell types. Although neurons represent the fundamental units of information processing in the CNS, a number of different glial cell types dynamically coordinate and modulate the final neuronal outputs. As a result, it is difficult to identify the relative contributions of individual cell types in the execution of complex CNS functions. Novel experimental tools for eliminating selected populations of glial cells are shedding light on the mechanisms underlying complex cell-to-cell interactions that influence the ultimate functionality of the brain and spinal cord. In particular, in vivo models of targeted cell death are making it possible to determine changes in natural phenomena in the absence of distinct subsets of glial cells, providing clues about the rol.. View More»
  

  Abstract PDF

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