Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Misao Iizuka
Japan
Research Article
Convenient Evaluation of Magnitude of Glomerulonephritis in BXSB/Mp Lupus Mice
Author(s): Emiko Takeuchi, Misao Iizuka, Masaya Tamura and Yasuo TakeuchiEmiko Takeuchi, Misao Iizuka, Masaya Tamura and Yasuo Takeuchi
Objective: Kidney involvement is one of the most important clinical features of systemic lupus erythematosus (SLE). Therefore, histopathological analysis of renal sections is necessary to evaluate the magnitude of lupus-like diseases. However, histopathological grading requires advanced pathological skills, otherwise the subjective views of the investigator can enter into evaluation. Here we show that in the case of a BXSB lupus mouse strain, the area and the long axis of glomeruli can be used as an objective index that can aid in the evaluation of the severity of lupus glomerulonephritis.Methods: Previously, we investigated the effects of treatment that involved the induction of bone marrow chimerism to BXSB lupus mice. Based on the results of histopathological analysis and immunofluorescence staining, the progression grades of lupus glomerulon.. View More»
DOI:
10.4172/2155-9899.1000209