ISSN: 2155-9880
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Mitchell Saltzberg
Tanzania
Research Article
Variability in Measurement of BNP in Routine Evaluation of Heart Failure(VAMPIRE)
Author(s): Pam R.Taub, Kevin Shah, Kevin Jiang, Paul Clopton, Mitchell Saltzberg, Alan S. Maisel and Robert L. Fitzgerald
Pam R.Taub, Kevin Shah, Kevin Jiang, Paul Clopton, Mitchell Saltzberg, Alan S. Maisel and Robert L. Fitzgerald
Background: B-type natriuretic peptide (BNP) is an established biomarker for diagnosis of acute heart failure (HF). However, criteria for interpreting BNP changes over time prior to clinical decompensation have not been well established.
Methods: BNP concentrations were followed in 192 patients with HF who had at least 5 BNP measurements over 6 month to 2 year period. Decompensation was defined as a hospitalization for HF. For patients (N = 30) who had a recent (within 2 weeks) BNP measured prior to decompensation, BNP concentrations were examined to determine if there was a significant rise prior to decompensation.
Results: For patients who had a BNP concentration measured within 2 weeks of decompensation, there was a significant increase in BNP concentration prior to decompensation. When patients with a baseline BNP &l.. View More»
DOI:
10.4172/2155-9880.S2-002