Journal of Clinical and Cellular Immunology
Open Access

Mohamad Hosein Niknam

Publications

• Research Article
  Pre-challenge Evaluation of Immune Response in Serum Cytokines (Th1 and Th2) and T-cell Markers (CD4, CD8, CD3, and CD25) Following Administration of New Formulated Leishmania Vaccine in Balb/c Mice
  Author(s): Afshineh Latifynia, Mohamad Hosein Niknam, Samad Farashi Bonab, Bita Ansaripour, Zahra Gheflati and Mohammad Javad Gharagozlou Afshineh Latifynia, Mohamad Hosein Niknam, Samad Farashi Bonab, Bita Ansaripour, Zahra Gheflati and Mohammad Javad Gharagozlou
  
  Leishmaniasis is considered an endemic disease that is a major public health concern in Iran and elsewhere. It is suggested that an effective immune response against leishmaniasis is T cells-mediated immunity that provides immunity against leishmania infection. The formulation and production of an immunogenic, effective, and safe vaccine to control leishmania infection is a necessity. Due to the complexity of the biological behavior of the leishmania parasite and its host immune response, the formulation and production of a safe and a protective vaccine is a difficult but worthwhile endeavor to tackle health problems. Methods: In this study, we evaluated pre-challenged immune responses related to the Th1 (IFN-gamma and IL-12) and Th2 (IL-4 and IL-10) cytokine profiles, and the CD4, CD8, CD3, and CD25 markers of T cells. This measur.. View More»
  DOI: 10.4172/2155-9899.1000533

  Abstract PDF

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