Journal of Drug Metabolism & Toxicology
Open Access

Mohamed Abdelrahim O

Publications

• Research Article
  Tamoxifen-Induced Lupus Erythematosus
  Author(s): Mohammed Mohammed EA, Sharief Nawahil A, Abukashawa Sumaia and Mohamed Abdelrahim O Mohammed Mohammed EA, Sharief Nawahil A, Abukashawa Sumaia and Mohamed Abdelrahim O
  
  Introduction: Anti Nuclear Antibodies are one of the auto antibodies which are involved in screening, diagnosis and pathology of some auto and non autoimmune and drug induced diseases including Lupus Erythrymatosus. Objectives: The aim of this study is to investigate, if there is any correlation between tamoxifen side effects and the blood levels of Anti Nuclear Antibodies as a consequence of drug-induced lupus erythematosus. Methods: Twenty-eight breast cancer patients under tamoxifen therapy were involved in this study and compared to 11 newly diagnosed breast cancer patients who did not receive any therapy. 5 mls of intravenous blood were collected from the subjects after informed consent was obtained. The plasma was separated and the ANA levels were determined using ELISA. Results: Seventeen patients under tamoxifen were found with high level of ANA while 11 patients were with normal.. View More»
  DOI: 10.4172/2157-7609.1000138

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