Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Mohamed Ali Attia Shafie
Faculty of Pharmacy,
Egypt
Research Article
In vitro and In vivo Evaluation of Timolol Maleate Ocular Inserts Using Different Polymers
Author(s): Mohamed Ali Attia Shafie and Mai Ahmed Hassan RadyMohamed Ali Attia Shafie and Mai Ahmed Hassan Rady
The present work focuses on treatment of glaucoma by formulating ocular inserts of different polymeric combination and Timolol maleate to enhance therapeutic effect through prolonging contact time with corneal surface, accurate, and sustain the release of the drug over a long period. The selected polymers for formulation of ocular inserts are Methyl Cellulose (MC), Hydroxypropyl cellulose (HPC), Eudragit RL100 (ERL100), Eudragit RS100 (ERS100), Ethylcellulose (EC), Polyvinylpyrrolidone (PVP). Films were plasticized using different plasticizers. The prepared ocular inserts were evaluated for their mechanical properties and physico-chemical properties. Accelerated stability studies were conducted to investigate the change in appearance, pH, and drug content after storage in drastic conditions. In vitro drug release and kinetics of drug release from different formulations were s.. View More»