Immunome Research
Open Access

Mohammed AA

Publications

• Research Article
  Epitope-Based Peptide Vaccine Design against Mokola Rabies Virus Glycoprotein G Utilizing In Silico Approaches
  Author(s): Mohammed AA, Hashim O, Elrahman KAA, Hamdi A and Hassan MA Mohammed AA, Hashim O, Elrahman KAA, Hamdi A and Hassan MA
  
  Background: Lyssavirus is considered as a neglected, zoonotic and tropical virus. Among all the Lyssavirus species known to exist today, Mokola virus is unique and appears to be exclusive to Africa. This virus is responsible for a meningoencephalomyelitis in mammals therefore; in silico prediction of epitopes of appropriate protein residues is important to produce a peptide vaccine with powerful immunogenic and minimal allergic effect. The aim of this study was to design a vaccine for Mokola virus using its glycoprotein peptides as an immunogen to stimulate protective immune response. Methods and materials: Glycoprotein G Sequences of Mokola was explored from NCBI then the sequences were aligned to obtain conserved regions. The nominees epitopes from Immune Epitope Database were analyzed by different prediction tools for B-cel.. View More»
  DOI: 10.4172/1745-7580.1000144

  Abstract PDF

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