Pharmaceutical Analytical Chemistry: Open Access
Open Access
ISSN: 2471-2698
+44 1478 350008
ISSN: 2471-2698
+44 1478 350008
Mohammed Hamid Said
Iraq
Research Article
Preparation, Characterization and Biological Evaluation of β-Lactam Derived
from 6-Amino Penicillinic Acid and Salicyldehyde
Author(s): Rasha Hasan Jasim, Mohammed Hamid Said and Batool Qusai Ali
Rasha Hasan Jasim, Mohammed Hamid Said and Batool Qusai Ali
The present report is concerned with the synthesis novel Schiff base ligand by condense 6-Amino Penicillinic acid with Salicyldehyde. The ligand was characterized by 1H-NMR, 13C-NMR, mass spectrometry, UV-Vis and FT-IR studies. The ligand have got more than one moiety which are capable of chelation, therefore complexes of Co(II), Ni(II), Cu(II), and Zn(II) were prepared. These complexes were characterized by UV-Vis, FT-IR, magnetic susceptibility and Molar conductivity studies. All these techniques indicate 1:2 stoichiometry of synthesized complexes. In all the complexes, Schiff base ligand acts as a tridentate ligand. Finally, the ligand and complexes have been screened for their antibacterial activity against four types of bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus facials and Proteus mirabilis) then it isolated from different classes of ulcerative infect.. View More»
DOI:
10.4172/2471-2698.1000125