Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Mohammed M. Abdel Salam
Egypt
Research Article
Multi-drug Resistant Proteins Expression in Retinoblastoma in Primary Enucleated Eyes Versus Eyes Enucleated after Failure of Conservative Treatment
Author(s): Hisham K. Abdel-Dayem, Mohammed M. Abdel Salam, Zafer F. Ismail, Othman A. Ziko and Wesam M. Osman
Hisham K. Abdel-Dayem, Mohammed M. Abdel Salam, Zafer F. Ismail, Othman A. Ziko and Wesam M. Osman
Objective: To compare expression of Multidrug-resistant protein 1/P-glycoprotein (MDR1/Pgp) in retinoblastoma in eyes treated by primary enucleation due to advanced tumor at initial presentation and those enucleated after being resistant to chemotherapy.
Design and methods: A prospective non randomized masked analysis of pathology specimens obtained from twenty retinoblastoma patients presenting at the retinoblastoma clinic at ophthalmology department, Ain Shams University Hospitals. Specimens from patients who had enucleation were divided into 2 groups. Patients in group 1 underwent primary enucleation due to advanced tumor at presentation. Patients in group 2 underwent secondary enucleation after failure of conservative treatment. Immuno histochemical studies were performed searching for expression of Multidrug-resistant protein 1/P-glycop.. View More»
DOI:
10.4172/2155-9570.1000684