Biochemistry & Pharmacology: Open Access
Open Access

Mokrani El Hassen

Publications

• Research Article
  Research of New Molecules Able to Starve the Tumors by Molecular Docking\'s Method
  Author(s): Chikhi Abdelouahab, Bensegueni Abderrahmane, Merzoug Amina, Hioual Khadidja Soulef and Mokrani El Hassen Chikhi Abdelouahab, Bensegueni Abderrahmane, Merzoug Amina, Hioual Khadidja Soulef and Mokrani El Hassen
  
  In recent years, a promising new approach uses the anti-angiogenesis properties of certain molecules to try to block cancer by depriving tumors of nutrients and oxygen they need to grow. Endothelial cells, specialized in the development of new blood vessels, are the target of most anti-angiogenic strategies, Or methionine aminopeptidase (MetAp) type 2 is a member of a family of proteins that regulates the growth of these endothelial cells. The molecular docking program, GOLD, was developed to assist in the development of molecules with therapeutic activity. It has been used to study the inhibition of 1QZY, human methionine aminopeptidase type 2, by bengamide derivatives, with the aim of discovering new anti-angiogenic drugs. The evaluation of the affinity of these molecules brought to light those presenting the best inhibitive effect. It is about the compound 16, the value of the scor.. View More»
  DOI: 10.4172/2167-0501.1000117

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