Journal of Proteomics & Bioinformatics
Open Access

Monalisa Tiwari

Publications

• Research Article
  In-silico Approach Explains Evolution of Beta-lactamases from Penicillin Binding Proteins
  Author(s): Privita Verma, Aditi Upadhyay, Monalisa Tiwari and Vishvanath Tiwari Privita Verma, Aditi Upadhyay, Monalisa Tiwari and Vishvanath Tiwari
  
  Penicillin binding proteins (PBPs) possess transpeptidase, transglycosylase as well as carboxypeptidase activities and mediates the crosslinking of N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) of peptidoglycan, thereby promoting the cell wall synthesis. The β-lactam antibiotics bind to PBPs and inactivate them, thus killing the bacteria. During the course of evolution, bacteria have also developed differential survival strategies. Emergence of multidrug resistance resulting from β-lactamases constitutes a worldwide threat. This enzyme hydrolyzes β-lactam antibiotics and thus makes them inactive. The purpose of this study was to analyze the binding affinity of β-lactam antibiotics with PBPs and β-lactamases by computational docking studies. For this, different classes of β-lactams know.. View More»
  DOI: 10.4172/jpb.1000413

  Abstract PDF

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