Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Monica Zhang
Tanzania
Research Article
Cancer Specific CTL Expansion with ZYX Bioreactor
Author(s): Yongxin Zhang, Ying Wang, Zhenxiang Wang, Monica Zhang and Zhenying WangYongxin Zhang, Ying Wang, Zhenxiang Wang, Monica Zhang and Zhenying Wang
Objective: The use of therapeutic immune cell subsets is becoming an increasingly cost-effective and attractive strategy for the treatment of cancer. Nonetheless, the field of cell therapy is hampered by the inability to consistently generate and expand sufficient numbers of high quality cells from a majority of patients. To address this critical issue, the investigators developed a sophisticated bioreactor technology that maximizes metabolic support and minimizes the damaging shear-stress forces, automatically monitors functional correlates to allow cell harvest at peak functional capacity, and permits cell sorting in situ to minimize cell loss and microbial contamination. In current study, the established cancer-specific CTL expansion system will be tested for its potency of cancer cell killing both in vitro and in vivo. Methods: To te.. View More»
DOI:
10.4172/2155-9899.1000398