ISSN: 2155-6148
+44 1223 790975
Montaser A Mohammad
Egypt
Research Article
Preoperative Oral Morphine and Sub-Anesthetic Ketamine Co-Administration
Reduce Acute Post-Mastectomy Pain
Author(s): Montaser A Mohammad and Diab Fuad Hetta
Montaser A Mohammad and Diab Fuad Hetta
Objectives: To assess the analgesic efficacy and tolerability of co-administration of pre-emptive single oral dose of sustained release morphine and sub- anesthetic ketamine infusion for modified radical mastectomy (MRM) with axillary evacuation.
Methods: Sixty four adult female patients scheduled for MRM were divided to two groups, morphine group (n=32) received preoperative oral sustained release morphine tablet, 30 mg and placebo group (n=32) received placebo tablet. Both groups received preoperative ketamine bolus, 0.5 mg/kg followed by continuous infusion 0.1 mg/kg/h for 24 h postoperatively. VAS pain score, time to first analgesic request, 24 h analgesic consumption were reported.
Results: The mean VAS pain score during movement was significantly decreased in morphine group in comparison to placebo group from.. View More»
DOI:
10.4172/2155-6148.1000728