Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Muddasir Basheer
India
Research Article
Receptor Cross Talk and Interplay between Melatonin and Ovarian Thyroid Axis in a Letrozole Induced Polycystic (Pco) Rat
Author(s): Hindole Ghosh, Seema rai, Muddasir Basheer and Younis Ahmad Hajam
Hindole Ghosh, Seema rai, Muddasir Basheer and Younis Ahmad Hajam
The objective of present study was to establish the interrelationship between thyroid and melatonin during anovulatory/letrozole induced polycystic ovarian condition on female Wister rats. Rats were procured and after acclimatization 20 rats were divided in 4 groups with 5 rats in each. They were divided as Control, Letrozole induced PCO rat (1 mg/kg BW/d), and melatonin alone (200 μg/100 g BW/d). The experiment was conducted for the duration of 28 d. Assessment of gravimetric, hormonal profile and thyroid histology and relative expression of MT1, MT2, and ERα, (thyroid, ovary) Dio2, TRα (Ovary) done followed by standard protocol. Histological observation showed shrinkages in thyroid follicles in PCO rats however exogenous melatonin maintained the cellular architecture and normal thyroid weight. PCO rats showed significantly high circulating testosterone but significant.. View More»
DOI:
10.4172/2155-9899.1000552