Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Murli Manohar
India
Research Article
Proteomic Identification and Analysis of Human Endometrial Proteins
Associated with Unexplained Infertility
Author(s): Murli Manohar, Huma Khan, Vinay Shukla, Vinita Das, Anjoo Agarwal, Amita Pandey, Waseem Ahmed Siddiqui and Anila DwivediMurli Manohar, Huma Khan, Vinay Shukla, Vinita Das, Anjoo Agarwal, Amita Pandey, Waseem Ahmed Siddiqui and Anila Dwivedi
Unexplained infertility (UI) represents about 25-30% of all known types of female infertility. To date, UI remains an unsolved problem in a subgroup of infertile but otherwise healthy women and the molecular causes of UI are not yet known. In the current study, we have compared and analyzed the proteomic profile of receptive phase (LH+7) endometrium from fertile and infertile women, with a view to identify the appropriate protein target signatures that may be responsible for defective endometrial receptivity as a cause of UI. 12 Differentially expressed proteins (8 up-regulated and 4 down-regulated) were identified by Liquid Chromatography-Mass Spectrometric analysis. These differentially expressed proteins were involved in immunological response, glycolytic pathway, lipid metabolism, blood agglutination, protein synthesis, molecular chaperone, antioxidant system, mitochondrial ATP ge.. View More»
DOI:
10.4172/jpb.1000340