Journal of Clinical Toxicology
Open Access

Muthumani M

Publications

• Research Article
  Tetrahydrocurcumin Potentially Attenuates Arsenic Induced Oxidative Hepatic Dysfunction in Rats
  Author(s): Muthumani MMuthumani M
  
  Arsenic (As) compounds are reported as environmental toxicants and human carcinogens. Exposure to arsenic imposes a big health issue worldwide. Tetrahydrocurcumin (THC) is an antioxidative substance, which is derived from curcumin, the component of turmeric. In view of this fact, the purpose of this study was to delineate the ameliorative role of THC against arsenic-induced hepatotoxicity in rats. In this context, we evaluated the mode of action of chronic oral exposure of sodium arsenite as the source of arsenic at 5 mg/kg/BW with THC (80 mg/ kg/BW) for 28 days. Hepatotoxicity was evaluated by the increased activities of serum hepatospecific enzymes namely aspartate transaminase, alanine transaminase, alkaline phosphatase, gamma glutamyl transferase, lactate dehydrogenase and total bilirubin along with increased elevation of lipid peroxidative markers, thiobarbituric acid reactive su.. View More»
  DOI: 10.4172/2161-0495.1000168

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