Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Nader M Mohamed
KSA
Research Article
Inflammatory Cytokines in Neonatal Hypoxic Ischemic Encephalopathy and their Correlation with Brain Marker S100 Protein: A Case Control Study in Saudi Arabia
Author(s): Adnan Amin Alsulaimani, Abdelaziz SA Abuelsaad and Nader M MohamedAdnan Amin Alsulaimani, Abdelaziz SA Abuelsaad and Nader M Mohamed
Background: Neonatal HIE is still one of the major causes of morbidity and mortality in the perinatal period. The effective management and early intervention for these infants depends on early identification of the condition. This study aimed to identifying biomarkers of inflammation in HIE in Saudi Arabia and their association with serum level of S100 protein.Patients and methods: 100 cases of full-term infants were classified into two groups. The first was comprised of normal healthy infants, while the second was composed of infants with hypoxic-ischemic encephalopathy. Blood gases, electrolytes, liver and renal functions were evaluated, along with some inflammatory cytokines IL1, IL6 and TNFα. Correlation between cytokine levels and S100 protein level was adjusted with time.Results: The.. View More»
DOI:
10.4172/2155-9899.1000289