Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Nadia Sukusu Nielsen
Denmark
Research Article
Insight into the Protein Composition of Immunoglobulin Light Chain Deposits of Eyelid, Orbital and Conjunctival Amyloidosis
Author(s): Nadia Sukusu Nielsen, Ebbe Toftgaard Poulsen, Gordon K Klintworth and Jan J EnghildNadia Sukusu Nielsen, Ebbe Toftgaard Poulsen, Gordon K Klintworth and Jan J Enghild
Amyloidosis is a disease characterized by the formation of extracellular amyloid deposits. Immunoglobulin lightchain amyloidosis can appear as a local disorder presenting with mild symptoms or as a life threatening systemic disease. The systemic form of immunoglobulin light-chain amyloidosis is the most common type of amyloidosis in western countries although it is a rare disease. Identification of the proteins forming amyloid fibrils is essential for the diagnosis of the disease and knowledge about the overall protein composition of the deposits may lead to a larger understanding of the deposition events thereby facilitating a more detailed picture of the molecular pathology. In this pilot study, we investigated the protein composition of amyloid deposits isolated from human specimens of the eyelid, conjunctiva, and orbit. Deposits and internal control tissue (patient tissue without .. View More»
DOI:
10.4172/jpb.S8-002