Translational Medicine
Open Access
ISSN: 2161-1025
ISSN: 2161-1025
Nagi B. Kumar
H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida College of Medicine,
12902 Magnolia Drive, Tampa, Florida
Tanzania
Review Article
Molecular Targeted Therapies Using Botanicals for Prostate Cancer Chemoprevention
Author(s): Nagi Kumar and Ganna ChornokurNagi Kumar and Ganna Chornokur
In spite of the large number of botanicals demonstrating promise as potential cancer chemopreventive agents, most have failed to prove effectiveness in clinical trials. Critical requirements for moving botanical agents to recommendation for clinical use include adopting a systematic, molecular-target based approach and utilizing the same ethical and rigorous methods that are used to evaluate other pharmacological agents. Preliminary data on a mechanistic rationale for chemoprevention activity as observed from epidemiological, in vitro and preclinical studies, phase I data of safety in suitable cohorts, duration of intervention based on time to progression of pre-neoplastic disease to cancer and using a valid panel of biomarkers representing the hypothesized carcinogenesis pathway for measuring efficacy must inform the design of clinical trials. Botan.. View More»
DOI:
10.4172/2161-1025.S2-005