Journal of Pharmaceutical Care & Health Systems
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Nagib Qarah

Publications

• Research Article
  Spectrophotometric Assay of Diethylcarbamazine Citrate in Pharmaceuticals and Human Urine via Ion-Pair Reaction Using Methyl Orange Dye
  Author(s): Nagib Qarah, Basavaiah K* and Sameer AM Abdulrahman Nagib Qarah, Basavaiah K* and Sameer AM Abdulrahman
  
  Two simple and moderately selective spectrophotometric methods are described for the determination of Diethylcarbamazine Citrate (DEC) in bulk drug, dosage forms and spiked human urine. The first method (method A) is based on the formation of yellow colored ion-pair complex between DEC and Methyl Orange (MO) dye, at pH 4.95 ± 0.05, which was extracted into chloroform and measured at 420 nm. The second method (method B) involved the breaking of yellow ion-pair complex in acid medium followed by the measurement of the free dye at 520 nm. Experimental parameters influencing the formation and extraction of the ion-pair complex in method A and breaking of the complex in method B were scrupulously examined and optimized. Beer’s law is obeyed over the concentration ranges of 10-90 and 5-100 μg mL-1 DEC with corresponding molar absorptivity values of 2.90×103 and 3.54&ti.. View More»
  DOI: 10.4172/2376-0419.1000182

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