Journal of Drug Metabolism & Toxicology
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Najam-us-Saquib

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• Research Article
  Effect of Reconstitution Solvents and Containers on Kinetics and Safety of Cephradine Neutralized with L-Arginine
  Author(s): Aman Ullah Khan, Javeid Iqbal, Saif-ur-Rehman Khattak and Najam-us-Saquib Aman Ullah Khan, Javeid Iqbal, Saif-ur-Rehman Khattak and Najam-us-Saquib
  
  The effect of reconstitution solvents such as water for injection, 0.5% metronidazole injection, 0.9% sodium chloride injection and 5% dextrose injection, has been investigated on the kinetics of degradation of cephradine neutralized with L-arginine contained in glass, polyvinylchloride (PVC) and polyethylene pthalate (PET) containers at 5, 15 and 30°C. The analytical method described in USP-31 for the analysis of cephradine injection was employed in this study after slight modification and validation in respect of specificity, linearity, accuracy and precision. The degradation of the compound showed first-order kinetics and the degradation rate constants ?kobs? were found in the range of 1.84-3.07 × 10-3 hr-1 (r2=0.990-0.999) at 5°C, 2.3-4.2 x 10-3 hr-1 (r2=0.993-0.999) at 15°C and 1.18-9.97 × 10-3 hr-1 (r2=0.998-0.999) at 30°C, respectively. The compound showed maximum stability in dex.. View More»
  DOI: 10.4172/2157-7609.1000150

  Abstract PDF

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