Autism-Open Access
Open Access

Nancy Thomas

Publications

• Case Report
  Intrathecal Autologous Bone Marrow Mononuclear Cell Transplantation in a Case of Adult Autism
  Author(s): Alok Sharma, Nandini Gokulchandran1, Hemangi Sane, Pooja Kulkarni, Nancy Thomas, Amruta Paranjape and Prerna Badhe Alok Sharma, Nandini Gokulchandran1, Hemangi Sane, Pooja Kulkarni, Nancy Thomas, Amruta Paranjape and Prerna Badhe
  
  Autism is a complex neurodevelopmental disorder with a worldwide prevalence of 1 in 88. With greater understanding of mechanism of action of cellular therapy it is now possible to address the pathogenesis of autism. Recent findings of cellular therapy offering immunomodulatory, angigogenetic and paracrine effects make it a lucrative option for treatment of autism. We administered a 33 year old adult patient of autism intrathecally, with autologous bone marrow mononuclear cells (BMMNCs), twice with an interval of six months. On follow up at 3, 6 and 9 months post first intervention, he was re-evaluated clinically and no major or minor side effects were observed. At 6 and 9 months objective outcome measures of Indian Scale for Assessment of Autism (ISAA) and Clinical Global Impression (CGI) were used and they showed significant improvement. At the end of 9 months, on ISAA, the score imp.. View More»
  DOI: 10.4172/2165-7890.1000113

  Abstract PDF

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