Immunome Research
Open Access

Naoshi Fukui

Publications

• Research Article
  Plasma Amino Acid Profiles in Collagen Disease Patients with Interstitial Lung Disease
  
  Author(s): Hiroshi Furukawa, Shomi Oka, Kenji Takehana, Takahiko Muramatsu, Kota Shimada, Akiko Komiya, Naoshi Fukui, Naoyuki Tsuchiya and Shigeto TohmaHiroshi Furukawa, Shomi Oka, Kenji Takehana, Takahiko Muramatsu, Kota Shimada, Akiko Komiya, Naoshi Fukui, Naoyuki Tsuchiya and Shigeto Tohma
  
  Interstitial lung disease (ILD) is frequently associated with collagen diseases, and is designated collagen vascular disease-associated ILD (CVD-ILD) that influences the prognosis of the disease. Acute-onset diffuse ILD (AoDILD) occurs in patients with collagen disease with or without underlying CVD-ILD. The prognosis of AoDILD is quite poor. It has been reported that plasma amino acid profiles are altered in rheumatoid arthritis (RA) patients. Here, we investigated the plasma amino acid profiles to determine whether they may be useful for diagnosing CVDILD or AoDILD in collagen disease. Plasma amino acid levels were analyzed using liquid chromatography/electrospray ionization tandem mass spectrometry in 64 RA patients with or without CVD-ILD, and 15 collagen disease patients with AoDILD. By using support vector machine (svm) analysis, the svm index (AA) was generated from ami.. View More»
  DOI: 10.4172/1745-7580.1000064

  Abstract

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