Organic Chemistry: Current Research
Open Access
ISSN: 2161-0401
+44 1478 350008
ISSN: 2161-0401
+44 1478 350008
Naoyuki Nishiya
School of Pharmacy 2-1-1 Nishitokuta, Yahaba-cho, Shiwa-gun, Iwate, 028-3694
Japan
Research Article
Chemical Modifier Screenings as Methods for Identifying Pathway-Targeting Compounds and for Predicting Drug-Drug Interactions
Author(s): Naoyuki Nishiya Naoyuki Nishiya
Screenings for genetic modifiers, such as suppressors or enhancers, in model organisms have identified and characterized important signaling pathways. Likewise, a phenotype induced by a chemical compound can be suppressed or enhanced by another compound. Here, I introduce chemical modifier screenings as phenotype-based assays that expand therapeutic targets to unexpected molecules and that facilitate identification of target signaling pathways. Also, chemical modifier screening can be applied to predicting possible drug-drug interactions that cause adverse effects... View More»
DOI:
10.4172/2161-0401.1000128