Reproductive System & Sexual Disorders: Current Research
Open Access

Nardin Aslih

Publications

• Case Report
  Congenital Adrenal Hyperplasia, the Origin of Combined Infertility: A Case Report and a Review of Literature
  Author(s): Nardin Aslih and Adrian Ellenbogen Nardin Aslih and Adrian Ellenbogen
  
  Congenital Adrenal Hyperplasia (CAH) – a complex and heterogeneous group of conditions is inherited as Autosomal Recessive (AR) disorders. The resultant deficiencies in one of the five enzymes involved in adrenal steroidogenesis lead to defects in the steroidogenic pathways and biosynthesis of cortisol, aldosterone and androgens. Precursor steroids proximal to the blocked step accumulate and can be shunted into other metabolic pathways, particularly that of androgen biosynthesis. CAH due to 21-Hydroxylase deficiency is traditionally separated into two clinical groups: the Classical form (CCAH), which is further separated into salt-wasting (75%) and simple-virilizing (25%) phenotypes, and the Nonclassical form (NC-CAH). They are differentiated by their hormonal profile, predominant clinical features and age of appearance. CAH can.. View More»
  DOI: 10.4172/2161-038X.1000142

  Abstract PDF

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